AP photo Notre Dame wide receiver Ben Skowronek (11) runs the ball in for a touchdown against Boston College defensive back Brandon Sebastian (10) during the first half of Saturday's 45-31 Irish win at Chestnut Hill.

BOSTON (AP) — Ian Book passed for three touchdowns and ran for another and No. 2 Notre Dame overcame an early deficit to roll to a 45-31 victory over Boston College on Saturday.

The Fighting Irish’s eighth straight win in the series between the FBS’s only Catholic institutions gave coach Brian Kelly his 100th career victory at the school, tying him with Lou Holtz for second all-time. He is now just five behind coach Knute Rockne.

Coming off a thrilling victory against Clemson, Notre Dame (8-0, 7-0 ACC) racked up a season-high 561 total yards against BC led by Book, who finished 20 of 27 for 283 yards.

He also ran for a 85 yards and a touchdown. Ben Skowronek caught all three of Book’s TD passes, but also had one of three Notre Dame fumbles on the day. C’Bo Flemister ran for two touchdowns before leaving the game in the fourth quarter with an apparent left leg injury.

Phil Jurkovec, a transfer from Notre Dame playing against his former team for the first time, finished 18 of 40 for 272 yards, a touchdown and interception for Boston College (5-4, 4-4).

Th Eagles hung tough in the first half, recovering a pair of Notre Dame fumbles, but they scored only six points of the miscues.

Their defense also had few answers for Book, who took advantage of the Irish’s length at receiver throughout the game to produce five pass plays of 20 or more yards.

The Eagles jumped out to a 10-3 lead in the first quarter before the Irish outscored them 28-6 the rest of the first half.

Boston College had a chance to cut into a 24-16 deficit late in the second quarter after Notre Dame’s Kryen Williams fumbled following a hit by BC’s Chibueze Onwuka. The ball was recovered by Isaiah McDuffie on the Irish 42.

But BC gave it right back three plays later when center Alec Lindstrom snapped the ball before Jurkovec was expecting it. It was recovered by Notre Dame defensive end Daelin Hayes on the Eagles 49 with 2:05 left in the quarter.

Notre Dame moved quickly and Book connected with Skowronek for the third time in the half, this time from 7 yards out, to make it 31-16.

In other key games Saturday:

NO. 6 FLORIDA 63, ARKANSAS 35

Kyle Trask threw for 356 yards and six touchdowns, extending his school record for consecutive games with at least four TDs to six, and No. 6 Florida overwhelmed Arkansas in the Swamp.

Trask repeatedly torched the Razorbacks (3-4), who were without coach Sam Pittman and without much of a chance by halftime. It was the second time this season Trask tossed six TDs in a game. He’s the only player in school history to accomplish that feat.

NO. 9 MIAMI 25, VA. TECH 24

After coming precariously close to not being able to play Virginia Tech because of COVID-19 issues, No. 9 Miami came away with one of its gutsiest victories of the season.

D’Eriq King threw for 255 yards and a touchdown and ran for a score, rallying the Hurricanes, who had announced it had 13 players unavailable before the game, including three starters and several offensive linemen.

The Hurricanes (7-1, 6-1 Atlantic Coast Conference) rallied from an 11-point, third-quarter deficit to win their fourth consecutive game and stay very much alive for a spot in the ACC championship game. They scored the game’s final 12 points and held the Hokies scoreless on their last five possessions.

NO. 10 INDIANA 24, MICHIGAN STATE 0

Ty Fryfogle had 11 catches for 200 yards — surpassing career highs he’d set just a week earlier — and the Hoosiers remained unbeaten, turning what looked like a potential trap game into an easy win.

Now, the Hoosiers can look ahead to a showdown next weekend at No. 3 Ohio State .Michael Penix Jr. threw for 320 yards and hit Fryfogle for two touchdown passes.

NO. 13 WISCONSIN 49, MICHIGAN 11

No. 13 Wisconsin was ready, not rusty, in its first game in three weeks.

Michigan, meanwhile, looked lost and lifeless in a third straight loss.

Nakia Watson and Mason Stokke each scored two touchdowns in the first half, helping the Badgers build a big lead in a rout of the Wolverines on Saturday night.

Wisconsin (2-0) returned to competition after canceling two games of its all-Big Ten schedule due to a COVID-19 breakout within the program and rolled past a hapless team.

The Wolverines (1-3) fell behind 28-0 at halftime, their largest deficit at home since the Big House opened in 1927, and finished with their most lopsided loss at home since a 1935 loss to Ohio State.

Wisconsin’s first two touchdowns — Watson’s 2-yard run and Graham Mertz’s 1-yard pass to Stokke — were four plays after Joe Milton’s passes were intercepted. The running back and fullback scored their second touchdowns on runs in the second quarter, giving the Badgers a 28-0 lead that was large enough against an offensively challenged team.

The Badgers finished with 341 yards rushing and five scores on the ground.

Mertz was 12 of 22 for 127 yards with two touchdowns.

NO. 16 MARSHALL 42, MIDDLE TENNESSEE 14

Quarterback Grant Wells grew up knowing the story of Marshall football. The 1970 plane crash. The university’s decision to continue playing. The winning years that eventually would come.

And the importance of representing the school and honoring the fallen on the crash’s big anniversary.

The redshirt freshman threw a season-high five touchdown passes and No. 16 Marshall commemorated the 50th anniversary of the worst disaster in U.S. sports history with a over Middle Tennessee on Saturday.

“We knew that this game was going to mean so much to this fan base and this community,” Wells said “That’s huge, no matter wherever we’re playing or whoever we’re playing. The fact that we could do this on the 50th anniversary is amazing.”

Marshall (7-0, 4-0 Conference USA) got another standout performance from its defense and turned three turnovers into scores on a day when the university remembered the 75 people killed on Nov. 14, 1970.

NO. 20 USC 34, ARIZONA 30

Vavae Malepeai bulled his way through multiple tacklers for an 8-yard touchdown run with 25 seconds left, and No. 20 Southern California survived with another late rally.

USC (2-0, 2-0 Pac-12) was outplayed by Arizona State last week before scoring two touchdowns in the final three minutes to win 28-27.

The Trojans again had two late scoring drives to win a game they were outplayed in for most of the afternoon.

Kevon Slovis hit Erik Krommenhoek on a 6-yard touchdown, but Arizona (0-1, 0-1) marched quickly down the field for a 6-yard touchdown pass from Grant Gunnell from Stanley Berryhill III with 1:20 left.