AP photo Clemson quarterback D.J. Uiagalelei (5) passes the ball during the first half Saturday's game against Boston College in South Carolina.

CLEMSON, S.C. (AP) — Freshman DJ Uiagalelei already made Clemson history by leading the biggest comeback in the history of Death Valley. He’ll get the chance to make even more next week with Trevor Lawrence ruled out for the showdown with No 4 Notre Dame due to COVID-19.

Uiagalelei stepped in for Lawrence on Saturday and rallied the top-ranked Tigers to a 34-28 victory over Boston College after they fell behind by 18 points.

Rattled at facing the Fighting Irish? The kid from California sure doesn’t sound like it.

“It’s the same mindset that I had this week,” Uiagalelei said. “Start watching some film tomorrow to get ready for another game.”

Smooth and calm, Uiagalelei looked ready-made for any challenge after leading Clemson back from 28-10 deficit, a rally that surpassed a 17-point come back from 35-18 down at home in a win over Virginia in 1966.

Boston College took advantage of the Clemson chaos early on with TDs on its first two series.

Phil Jurkovec found Zay Flowers for an 18-yard TD pass to put the Tigers behind for the first time all season. A short time later, it was David Bailey’s 2-yard scoring run that put the Eagles ahead 14-7.

NO. 4 NOTRE DAME 31, GA. TECH 13

Kyren Williams ran for two touchdowns, Ian Book passed for another and No. 4 Notre Dame turned in a dominant defensive performance.

Next up for the Fighting Irish: a showdown against top-ranked Clemson in South Bend.

“This is an awesome opportunity,” defensive end Daelin Hayes said. “We don’t have to beat around the bush anymore. It’s Clemson week, baby.!”

Book completed 18 of 26 passes for 199 yards in another efficient performance. Williams shook off a fumble that Georgia Tech returned for a long touchdown, scoring on runs of 2 and 4 yards. He finished with 76 yards on 15 carries.

In other key games Saturday:

NO. 2 ALABAMA 41, MISSISSIPPI STATE 0

Alabama still has DeVonta Smith, another playmaking wide receiver who’s awfully hard to defend.

Mac Jones threw four touchdown passes to Smith and the wideout had 203 yards receiving as the second-ranked Crimson Tide began life without Jaylen Waddle on Saturday night.

NO. 3 OHIO STATE 38, NO. 18 PENN STATE 25

Justin Fields passed for 318 yards and four touchdowns, two to Chris Olave, and No. 3 Ohio State beat No. 18 Penn State on an eerily quiet Saturday night at what is usually one of the most raucous settings in college football.

Jeremy Ruckert also caught a pair of touchdowns, Master Teague II ran for another and the Buckeyes generated 526 yards of offense in their 15th straight Big Ten win and 10th straight on the road against a ranked opponent.

Ohio State (2-0) didn’t take long to break the game open and hand Penn State (0-2) its first 0-2 start since 2013.

TEXAS 41, NO. 6 OKLAHOMA STATE 34 (OT)

Joshua Moore didn’t have a catch in regulation.

Sam Ehlinger didn’t care. His 15-yard touchdown pass to Moore in overtime helped Texas knock off previously unbeaten Oklahoma State.

Moore was Texas’ leader in catches and receiving yards and touchdowns heading into the game, so Ehlinger was confident that he would come through. Moore’s only reception gave the Longhorns the lead for good.

Texas linebacker Joseph Ossai sealed the victory by sacking Oklahoma State quarterback Spencer Sanders on fourth down in overtime. Ossai finished with 12 tackles, six tackles for loss, three sacks and a forced fumble.

NO. 8 TEXAS A&M 42, ARKANSAS 31

Kellen Mond threw for 260 yards and three touchdowns as eighth-ranked Texas A&M built a big lead and held on, extending its winning streak over the Razorbacks to nine games.

Jalen Wydermyer had a career-high 92 yards receiving with two touchdowns. Ainias Smith ran for a touchdown and caught a TD pass in the first half to help A&M win its third straight since losing to No. 2 Alabama.

NO. 10 FLORIDA 41, MISSOURI 17

Kadarius Toney scored three times, Kyle Trask became the first player in school history with four touchdown passes in four consecutive games and No. 10 Florida returned from a three-week layoff to handle on Saturday night in the Swamp.

The Gators’ easiest win of the season came after a COVID-19 outbreak forced the Southeastern Conference to postpone two of their games. It also included a benches-clearing scuffle at halftime that involved both coaches.

Several players threw punches during the melee, but just three were ejected. The conference could hand down more punishments following a review.

It could be costly for Florida (3-1), which plays rival and fifth-ranked Georgia next week in nearby Jacksonville. The game is likely to decide the winner of the SEC’s East Division.

MICHIGAN STATE 27, NO. 13 MICHIGAN 24

Rocky Lombardi threw for 323 yards, including 196 to Ricky White, and three touchdowns to help Michigan State stun the Michigan Wolverines

“I know we were three-touchdown underdogs, but everybody on this team knew going into the game that we had a chance and we had a good chance,” Lombardi said.

The Spartans (1-1, 1-1 Big Ten) appeared to be the better team all afternoon on both sides of the ball in Mel Tucker’s debut as coach in the rivalry.